Martina Ruglioni

Martina Ruglioni is a Resident in Clinical Pharmacology and Toxicology and a PhD student in Clinical and Translational Sciences, at the University of Pisa. Her research activity focuses on the detection of predictive and prognostic biomarkers in liquid biopsy using Next-Generation Sequencing.

Her PhD project, which she is carrying out at Unit of Clinical Pharmacology and Pharmacogenetics, University of Pisa, explores the use of liquid biopsy in the detection of germline mutations which can affect drugs’ metabolism leading to treatment toxicity/treatment failure, and the detection of somatic mutations in circulating free DNA extracted from plasma, in order to monitor patients’ response and resistance to treatment.

The importance of such minimally invasive, sensitive, repeatable, feasible alternative to tissue biopsy with the ability to capture heterogeneity across multiple areas of tumor needs to be evaluated.